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Fetal Alcohol Spectrum Disorder

MedGen UID:
457516
•Concept ID:
C2985290
•
Congenital Abnormality; Disease or Syndrome
Synonyms: Alcohol-Related Birth Defects (ARBD) - type; Alcohol-Related Neurodevelopmental Disorder (ARND) - type; Fetal Alcohol Syndrome (FAS) - type
SNOMED CT: Fetal Alcohol Spectrum Disorder (609437000)
 
Monarch Initiative: MONDO:0000408

Definition

A group of disorders caused by a prenatal exposure to maternal consumption of alcohol leading to a range of behavioral, cognitive and neurological deficits in the offspring. It is characterized by physical growth problems, distinct facies, and varying psycho-neurological issues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFetal Alcohol Spectrum Disorder

Professional guidelines

PubMed

Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder.
Wozniak JR, Riley EP, Charness ME
Lancet Neurol 2019 Aug;18(8):760-770. Epub 2019 May 31 doi: 10.1016/S1474-4422(19)30150-4. PMID: 31160204Free PMC Article
Postnatal nutritional treatment of neurocognitive deficits in fetal alcohol spectrum disorder.
Bastons-Compta A, Astals M, Andreu-Fernandez V, Navarro-Tapia E, Garcia-Algar O
Biochem Cell Biol 2018 Apr;96(2):213-221. Epub 2017 Nov 1 doi: 10.1139/bcb-2017-0085. PMID: 29091739
Fetal Alcohol Spectrum Disorders: Characteristics, Complications, and Treatment.
Wilhoit LF, Scott DA, Simecka BA
Community Ment Health J 2017 Aug;53(6):711-718. Epub 2017 Feb 6 doi: 10.1007/s10597-017-0104-0. PMID: 28168434

Recent clinical studies

Etiology

Why do women consume alcohol during pregnancy or while breastfeeding?
Popova S, Dozet D, Akhand Laboni S, Brower K, Temple V
Drug Alcohol Rev 2022 May;41(4):759-777. Epub 2021 Dec 28 doi: 10.1111/dar.13425. PMID: 34963039Free PMC Article
Alcohol's Impact on the Fetus.
Popova S, Dozet D, Shield K, Rehm J, Burd L
Nutrients 2021 Sep 29;13(10) doi: 10.3390/nu13103452. PMID: 34684453Free PMC Article
Alcohol use in pregnancy and its impact on the mother and child.
Oei JL
Addiction 2020 Nov;115(11):2148-2163. Epub 2020 Jun 3 doi: 10.1111/add.15036. PMID: 32149441
Adolescent Alcoholic Liver Disease.
Taylor SA, Miloh T
Clin Liver Dis 2019 Feb;23(1):51-54. Epub 2018 Oct 26 doi: 10.1016/j.cld.2018.09.003. PMID: 30454832
Metabolomics and fetal alcohol spectrum disorder.
Goldberg EM, Aliani M
Biochem Cell Biol 2018 Apr;96(2):198-203. Epub 2017 Jul 7 doi: 10.1139/bcb-2017-0080. PMID: 28686845

Diagnosis

Alcohol use in pregnancy and its impact on the mother and child.
Oei JL
Addiction 2020 Nov;115(11):2148-2163. Epub 2020 Jun 3 doi: 10.1111/add.15036. PMID: 32149441
Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder.
Wozniak JR, Riley EP, Charness ME
Lancet Neurol 2019 Aug;18(8):760-770. Epub 2019 May 31 doi: 10.1016/S1474-4422(19)30150-4. PMID: 31160204Free PMC Article
Alcohol Use in Pregnancy.
Dejong K, Olyaei A, Lo JO
Clin Obstet Gynecol 2019 Mar;62(1):142-155. doi: 10.1097/GRF.0000000000000414. PMID: 30575614Free PMC Article
Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis.
Lange S, Probst C, Gmel G, Rehm J, Burd L, Popova S
JAMA Pediatr 2017 Oct 1;171(10):948-956. doi: 10.1001/jamapediatrics.2017.1919. PMID: 28828483Free PMC Article
Fetal Alcohol Spectrum Disorders: Characteristics, Complications, and Treatment.
Wilhoit LF, Scott DA, Simecka BA
Community Ment Health J 2017 Aug;53(6):711-718. Epub 2017 Feb 6 doi: 10.1007/s10597-017-0104-0. PMID: 28168434

Therapy

Why do women consume alcohol during pregnancy or while breastfeeding?
Popova S, Dozet D, Akhand Laboni S, Brower K, Temple V
Drug Alcohol Rev 2022 May;41(4):759-777. Epub 2021 Dec 28 doi: 10.1111/dar.13425. PMID: 34963039Free PMC Article
Alcohol's Impact on the Fetus.
Popova S, Dozet D, Shield K, Rehm J, Burd L
Nutrients 2021 Sep 29;13(10) doi: 10.3390/nu13103452. PMID: 34684453Free PMC Article
Alcohol Use in Pregnancy.
Dejong K, Olyaei A, Lo JO
Clin Obstet Gynecol 2019 Mar;62(1):142-155. doi: 10.1097/GRF.0000000000000414. PMID: 30575614Free PMC Article
Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis.
Lange S, Probst C, Gmel G, Rehm J, Burd L, Popova S
JAMA Pediatr 2017 Oct 1;171(10):948-956. doi: 10.1001/jamapediatrics.2017.1919. PMID: 28828483Free PMC Article
Human alcohol-related neuropathology.
de la Monte SM, Kril JJ
Acta Neuropathol 2014 Jan;127(1):71-90. Epub 2013 Dec 27 doi: 10.1007/s00401-013-1233-3. PMID: 24370929Free PMC Article

Prognosis

Characterising fetal alcohol spectrum disorder in Canada: a national database protocol study.
Cook J, Unsworth K, Flannigan K
BMJ Open 2021 Sep 6;11(9):e046071. doi: 10.1136/bmjopen-2020-046071. PMID: 34489270Free PMC Article
Fetal alcohol spectrum disorder: neurodevelopmentally and behaviorally indistinguishable from other neurodevelopmental disorders.
Lange S, Shield K, Rehm J, Anagnostou E, Popova S
BMC Psychiatry 2019 Oct 28;19(1):322. doi: 10.1186/s12888-019-2289-y. PMID: 31660907Free PMC Article
High-risk follow-up: Early intervention and rehabilitation.
Novak I, Morgan C
Handb Clin Neurol 2019;162:483-510. doi: 10.1016/B978-0-444-64029-1.00023-0. PMID: 31324326
Association Analysis: Fetal Alcohol Spectrum Disorder and Hypertension Status in Children and Adolescents.
Cook JC, Lynch ME, Coles CD
Alcohol Clin Exp Res 2019 Aug;43(8):1727-1733. Epub 2019 Jun 24 doi: 10.1111/acer.14121. PMID: 31166027
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
Roozen S, Peters GJ, Kok G, Townend D, Nijhuis J, Curfs L
Alcohol Clin Exp Res 2016 Jan;40(1):18-32. doi: 10.1111/acer.12939. PMID: 26727519

Clinical prediction guides

Fetal alcohol spectrum disorder resources for health professionals: a scoping review.
Stubbs T, Cannon L, Carter E, Naanai H, Okurame JC, Martiniuk ALC, Davies J, Thomas S, Bedford M, Elliott EJ, Rice LJ
BMJ Open 2024 Jul 13;14(7):e086999. doi: 10.1136/bmjopen-2024-086999. PMID: 39002966Free PMC Article
Synaptic Plasticity Abnormalities in Fetal Alcohol Spectrum Disorders.
Basavarajappa BS, Subbanna S
Cells 2023 Jan 29;12(3) doi: 10.3390/cells12030442. PMID: 36766783Free PMC Article
High-risk follow-up: Early intervention and rehabilitation.
Novak I, Morgan C
Handb Clin Neurol 2019;162:483-510. doi: 10.1016/B978-0-444-64029-1.00023-0. PMID: 31324326
Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review.
Lange S, Rovet J, Rehm J, Popova S
BMC Psychol 2017 Jun 23;5(1):22. doi: 10.1186/s40359-017-0191-2. PMID: 28645298Free PMC Article
Ocular involvement in fetal alcohol spectrum disorder: a review.
Brennan D, Giles S
Curr Pharm Des 2014;20(34):5377-87. doi: 10.2174/1381612820666140205144114. PMID: 24502600

Recent systematic reviews

Fetal alcohol spectrum disorders screening tools: A systematic review.
Lim YH, Watkins RE, Jones H, Kippin NR, Finlay-Jones A
Res Dev Disabil 2022 Mar;122:104168. Epub 2022 Jan 4 doi: 10.1016/j.ridd.2021.104168. PMID: 34996007
Why do women consume alcohol during pregnancy or while breastfeeding?
Popova S, Dozet D, Akhand Laboni S, Brower K, Temple V
Drug Alcohol Rev 2022 May;41(4):759-777. Epub 2021 Dec 28 doi: 10.1111/dar.13425. PMID: 34963039Free PMC Article
Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis.
Lange S, Probst C, Gmel G, Rehm J, Burd L, Popova S
JAMA Pediatr 2017 Oct 1;171(10):948-956. doi: 10.1001/jamapediatrics.2017.1919. PMID: 28828483Free PMC Article
Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review.
Lange S, Rovet J, Rehm J, Popova S
BMC Psychol 2017 Jun 23;5(1):22. doi: 10.1186/s40359-017-0191-2. PMID: 28645298Free PMC Article
Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis.
Popova S, Lange S, Shield K, Mihic A, Chudley AE, Mukherjee RAS, Bekmuradov D, Rehm J
Lancet 2016 Mar 5;387(10022):978-987. Epub 2016 Jan 6 doi: 10.1016/S0140-6736(15)01345-8. PMID: 26777270

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